Potential predictive value of CD8A and PGF protein expression in gastric cancer patients treated with neoadjuvant immunotherapy

Immunoneoadjuvant therapy has gained significant attention due to its remarkable advancements in cancer treatment. This study aimed to investigate the molecular mechanisms underlying immunoneoadjuvant therapy through a comprehensive multiomics analysis of samples from a registered clinical trial cohort.

Citation:
Zhang C, Wang T, Yuan J, Wang T, Ma B, Xu B, Bai R, Tang X, Zhang X, Wu M, Lei T, Xu W, Guo Y, Li N. Potential predictive value of CD8A and PGF protein expression in gastric cancer patients treated with neoadjuvant immunotherapy. BMC Cancer. 2025;25(1).

Keywords:
CD8A; Gastric adenocarcinoma; Neoadjuvant immunotherapy; Olink proteomics; PGF; Sindillimab

Abstract:
Immunoneoadjuvant therapy has gained significant attention due to its remarkable advancements in cancer treatment. This study aimed to investigate the molecular mechanisms underlying immunoneoadjuvant therapy through a comprehensive multiomics analysis of samples from a registered clinical trial cohort.