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Research
Many Healthy LungsIn partnership with Derbarl Yerrigan Health Service and the Broome Regional Aboriginal Medical Service, we aim to improve Aboriginal lung health by determining for the first time the baseline lung function of Aboriginal Australians.
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Mechanisms of Acute Viral Respiratory Illness in Children (MAVRIC)Large numbers of children need emergency medical treatment each year for respiratory illnesses, particularly for wheezing and asthma.
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T regulatory cells in childhood asthmaAsthma is a chronic disease of the airways, most commonly driven by immuno-inflammatory responses to ubiquitous airborne antigens.
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A case-crossover analysis of traffic-related air pollution and emergency department presentations for asthma in PerthTo determine whether changes in 24-hour average background ozone (O₃), nitrogen dioxide (NO₂), carbon monoxide (CO) and particulates < 10 μm (PM₁₀) increase the
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Does genetic regulation of IgE begin in utero?Elucidation of early life factors is critical to understand the development of allergic diseases, especially those manifesting in early life such as food allerg
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Modulation of the postnatal maturation of immune function during early life: studies on the effects of natural infections and exposure to the bacterial-derived immunoenhancer OM85Severe winter lower respiratory infections in early life are known to be major risk factors for subsequent development of asthma, and it is also known that the high susceptibility to these infections in infants is due to the functional immaturity of their immune systems.
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The role of bacterial infections during infancy in asthma developmentIn this project we are studying how interactions between bacteria and viruses in children's airways promote the development of allergy and asthma.
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Genome-wide association study of IgG1 responses to the choline-binding protein PspC of Streptococcus pneumoniaeDelayed development of antibodies to S. pneumoniae in infancy is associated with the development of atopy and asthma.
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The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma DevelopmentLung inflammation resulting from ARIs during infancy is linked to asthma development.
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The influence of sighing respirations on infant lung function measured using multiple breath washout gas mixing techniquesThere is substantial interest in studying lung function in infants, to better understand the early life origins of chronic lung diseases such as asthma.