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Acute rheumatic fever (ARF), an autoimmune reaction to Group A Streptococcus (Streptococcus pyogenes; Strep A) infection, can cause rheumatic heart disease (RHD). New formulations of long-acting penicillins are being developed for secondary prophylaxis of ARF and RHD.
The pathogenesis of acute rheumatic fever (ARF) is poorly understood, limiting the development of immune-modulating therapies to treat disease and prevent progressive heart damage. Here, participants with definite ARF were compared to other severe acute paediatric conditions and matched healthy controls by profiling circulating immune molecules and cells to inform disease mechanisms and potential druggable pathways.
This prospective cohort study, which recruited participants with definite ARF in Australia and Aotearoa New Zealand, profiled circulating immune molecules and cells to inform disease mechanisms and future druggable pathways.
We want to hear from siblings living outside of Australian cities!
Our researchers want to know if starting a gluten-free diet reduces daily glycaemic variability in children and young people with both type 1 diabetes and newly-diagnosed coeliac disease.
To see if giving insulin by mouth (in a capsule) will delay or prevent T1DM in people at increased risk of developing diabetes.
If you, or your child is aged between 2 – 18 years and has type 1 diabetes, we invite you to complete a few questions to help us see how you manage your hypos at home.
Every year, over 80,000 Western Australian children will have a diagnosed mental health disorder.
Present a valuable resource for drug discovery and have identified ROM as a promising therapeutic for MLL-rearranged iALL
We undertook a retrospective review of children diagnosed with acute lymphoblastic leukemia (ALL) and treated with modern COG protocols to determine...