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Syphilis remains a global public health concern, particularly in pregnancy due to the risk of congenital syphilis. The WHO recommends benzathine penicillin G (BPG) as the standard treatment in pregnant women, whilst the optimal dosing strategy has not been established, particularly in relation to the impact of gestational age. This study sought to characterize the pharmacokinetics (PK) of a three-dose regimen of intramuscular BPG, given at weekly intervals, in pregnant women with syphilis.
Parental severe mental illnesses (SMIs), including schizophrenia, bipolar disorder, and major depressive disorder (MDD), can impact children's well-being, yet existing meta-analyses are limited in scope and methodology and do not comprehensively assess cognitive and academic performance in offspring across SMIs.
Many approved oral paediatric medicines continue to have poor taste acceptance, suggesting that the ingredient blends employed in these medicines are not adequately effective in taste-masking drugs with strongly aversive tastes. To address this inadequacy, this narrative review provides a comparative evaluation of taste-masking ingredients used by the pharmaceutical industry with those employed in the food industry, as well as food items used by caregivers to mask the unpalatable taste of medicines for young children.
Digital interventions have emerged as promising tools to support mental well-being in diabetes. This review aimed to evaluate the effectiveness of digital health interventions in improving mental health outcomes among adults with diabetes, as well as assess the methodological quality of relevant studies and provide a commentary on research gaps and future directions.
Citation: MacDonald B, Burmaz M, Baker S, et al. TrialR: critical enablers and the need for reusable Rare Disease Clinical Trial infrastructure in
The ORIGINS Project is a decade-long longitudinal study of more than 18,000 individuals including mothers, partners and children, as part of a collaboration between The Kids Research Institute Australia and Joondalup Health Campus.
New dads can feel undervalued and face significant health and mental health risks following the birth of a child, according to new research that has prompted a rethink about how to address the often-unmet needs of fathers.
Affecting approximately 400 people in Australia, Rett syndrome is a rare neurological disorder that occurs almost exclusively in girls and affects mobility and development, impacting everything from walking and talking to eating and breathing.
Culturally secure intervention to facilitate medical follow up for Aboriginal children, after being hospitalised with chest infections, have proven to improve long-term lung health outcomes.
The Perioperative Medicine team has developed a unique chewable tablet that gives the child the sensation of having a full stomach, without compromising their fasting regime.