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The bioenergetics of inflammation: insights into obesity and type 2 diabetesDiabetes mellitus is one of the most common chronic metabolic disorders worldwide, and its incidence in Asian countries is alarmingly high.
Research
Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRIThis study aimed to identify a CIS peripheral blood signature that may provide clues for potential immunomodulatory approaches early in disease
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Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease.We propose that this system provides a model for the differentiation and adaptation of monocytes entering the intestinal lamina propria.
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Molecular actions of Vitamin D in reproductive cell biologyThe aim of this work is to review current metabolic and molecular aspects of the VitD-VitD receptor axis in reproductive medicine
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Directing immune development to curb sky-rocketing diseaseOnce upon a time it was infectious diseases like polio, measles or tuberculosis that most worried parents. With these threats now largely under control, parents face a new challenge – sky-rocketing rates of non-infectious diseases such as asthma, allergies and autism.
Research
Assessing neutrophil subsets in autoimmune disease: Moving away from relying on density?Neutrophils are the most abundant immune cell in circulation. However, due to a number of technical challenges for researchers, including the neutrophil's short lifespan and difficulties with preservation, they are often discarded during blood processing and thus ignored in cohort studies. As such, the contribution of neutrophils to disease and their involvement in disease mechanisms is less explored compared with other immune cell types.
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Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothersWe sought to assess whether the trajectory to asthma begins already at birth and whether epigenetic mechanisms, contribute to asthma inception.
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Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: clues to the development of multiple sclerosisThese results indicate that T regulatory (Treg) and follicular T regulatory (Tfr) impairment is an early feature in MS.
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Sub-erythemal ultraviolet radiation reduces metabolic dysfunction in already overweight miceExposure to sunlight may limit cardiometabolic risk.
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Are low sun exposure and/or Vitamin D risk factors for type 1 diabetesEvidence supports that higher sun exposure and/or vitamin D sufficiency in pregnancy, or supplementation in early life, decreases type 1 diabetes risk