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Our goal was to identify genetic risk factors for severe otitis media (OM) in Aboriginal Australians.
Exome sequencing is widely used in the diagnosis of rare genetic diseases and provides useful variant data for analysis of complex diseases. There is not always adequate population-specific reference data to assist in assigning a diagnostic variant to a specific clinical condition.
Rheumatic heart disease (RHD) after group A streptococcus (GAS) infections is heritable and prevalent in Indigenous populations. Molecular mimicry between human and GAS proteins triggers proinflammatory cardiac valve-reactive T cells.
Overall the analyses do not suggest individual sequence variants account for differences in clinical outcome or adaptation to different hosts.
MMP1 is regulated by factors other than FLI1, and that the influence of IL-6 on MMP1 was independent of its effect on FLI1 in Leishmania braziliensis
Our results imply a role for IgG-mediated inflammation in determining delayed-type hypersensitivity associated with asymptomatic leishmaniasis
Resulting data represents the consequence of transcriptional regulation in each analyzed state of mammalian cells.
These results highlight how UNICORN can enable reliable, powerful, and convenient genetic association analyses without access to the individual-level data
Findings from this study indicate that even in the absence of stroke, being at high polygenic risk of ischemic stroke is associated with lower cognitive ability
TNF mRNA expression was higher in leprosy patients compared to endemic controls, but did not differ significantly between clinical subgroups